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Found 5 result(s)

Project Achilles

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Project Achilles is a systematic effort aimed at identifying and cataloging genetic vulnerabilities across hundreds of genomically characterized cancer cell lines. The project uses genome-wide genetic perturbation reagents (shRNAs or Cas9/sgRNAs) to silence or knock-out individual genes and identify those genes that affect cell survival. Large-scale functional screening of cancer cell lines provides a complementary approach to those studies that aim to characterize the molecular alterations (e.g. mutations, copy number alterations) of primary tumors, such as The Cancer Genome Atlas (TCGA). The overall goal of the project is to identify cancer genetic dependencies and link them to molecular characteristics in order to prioritize targets for therapeutic development and identify the patient population that might benefit from such targets. Project Achilles data is hosted on the Cancer Dependency Map Portal (DepMap) where it has been harmonized with our genomics and cellular models data. You can access the latest and all past datasets here: https://depmap.org/portal/download/all/

International Neuroimaging Data-sharing Initiative

INDI

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INDI was formed as a next generation FCP effort. INDI aims to provide a model for the broader imaging community while simultaneously creating a public dataset capable of dwarfing those that most groups could obtain individually.

Cancer Cell Line Encyclopedia

CCLE

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The Cancer Cell Line Encyclopedia project is a collaboration between the Broad Institute, and the Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer patient stratification. The CCLE provides public access to genomic data, analysis and visualization for about 1000 cell lines.

Marine Data Archive

MDA

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The Marine Data Archive (MDA) is an online repository specifically developed to independently archive data files in a fully documented manner. The MDA can serve individuals, consortia, working groups and institutes to manage data files and file versions for a specific context (project, report, analysis, monitoring campaign), as a personal or institutional archive or back-up system and as an open repository for data publication.

LEDAS

LEicester Database and Archive Service

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The Leicester Database and Archive Service (LEDAS) is an easy to use on-line astronomical database and archive access service, dealing mainly with data from high energy astrophysics missions, but also providing full database functionality for over 200 astronomical catalogues from ground-based observations and space missions. The LEDAS also allows access to images, spectra and light curves in graphics, HDS and FITS formats, as well as access to raw and processed event data. LEDAS provides the primary means of access for the UK astronomical community to the ROSAT Public Data Archive, the ASCA Public Data Archive and the Ginga Products Archive by its Archive Network Interface ARNIE.