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AceView provides a curated, comprehensive and non-redundant sequence representation of all public mRNA sequences (mRNAs from GenBank or RefSeq, and single pass cDNA sequences from dbEST and Trace). These experimental cDNA sequences are first co-aligned on the genome then clustered into a minimal number of alternative transcript variants and grouped into genes. Using exhaustively and with high quality standards the available cDNA sequences evidences the beauty and complexity of mammals’ transcriptome, and the relative simplicity of the nematode and plant transcriptomes. Genes are classified according to their inferred coding potential; many presumably non-coding genes are discovered. Genes are named by Entrez Gene names when available, else by AceView gene names, stable from release to release. Alternative features (promoters, introns and exons, polyadenylation signals) and coding potential, including motifs, domains, and homologies are annotated in depth; tissues where expression has been observed are listed in order of representation; diseases, phenotypes, pathways, functions, localization or interactions are annotated by mining selected sources, in particular PubMed, GAD and Entrez Gene, and also by performing manual annotation, especially in the worm. In this way, both the anatomy and physiology of the experimentally cDNA supported human, mouse and nematode genes are thoroughly annotated.
The goals of the Drosophila Genome Center are to finish the sequence of the euchromatic genome of Drosophila melanogaster to high quality and to generate and maintain biological annotations of this sequence. In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element-mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up-to-date information about the annotated sequence to the research community.
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The National Tropical Plant Germplasm Repository, supported by the Institute of Tropical Crop Variety Resources of the Chinese Academy of Tropical Agricultural Sciences (CATAS) and jointly constructed by 11 units including the Institute of Fruit Tree Research of the Guangdong Academy of Agricultural Sciences and Hainan University, aims to provide information and physical support for scientific and technological innovation in tropical crop seed industry, increase the income of farmers in hot regions, alleviate poverty, the "One Belt One Road" initiative and the National Tropical Agricultural Science Centre. The National Centre for Tropical Agricultural Sciences (NCTAS) provides information and physical support for tropical crop germplasm resources. The National Tropical Plant Germplasm Repository consists of a national medium-term tropical crop germplasm preservation repository, a medium-term tropical forage preservation repository and 12 national nurseries, covering 24 crops in nine categories, including rubber trees, tropical forage, tropical fruit trees, tropical oilseeds, tropical aromatic beverages, southern medicine, tropical grains, tropical flowers and tropical special vegetables, with more than 26,000 copies of resources, accounting for more than 90% of the total tropical crop germplasm resources in China. The resources account for more than 90% of the total amount of tropical crop germplasm resources in China. It has built an efficient management system and a stable human resources team, a conservation system that combines centralized conservation in germplasm banks and moderate distribution in germplasm nurseries, a technical specification system for the unified description of germplasm resources of major tropical crops, and an integrated system for the conservation and utilization of China's tropical crop germplasm resource information network, ensuring the efficient operation and sustainable development of the national tropical crop germplasm resource bank.
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The National Microbial Resource Center (NMRC) is an important part of the national science and technology resources sharing service platform, responsible for the research, conservation, management and sharing of national microbial strain resources, ensuring the strategic security and sustainable use of microbial strain resources, and providing support for scientific and technological innovation, industrial development and social progress. The main tasks of the NMRC are: to collect, organize and preserve microbial strain resources around national needs and scientific research; to undertake the task of remitting, organizing and preserving strain resources resulting from the implementation of science and technology projects; to be responsible for the development and improvement of microbial strain resource standards, and to standardize and guide the development of microbial strain resources in various fields. The company is responsible for the development and improvement of microbial strain resource standards, standardizing and guiding the protection and utilization of microbial strain resources in various fields; building and maintaining the national strain resource online service system, and carrying out social sharing of physical and information resources of strains; developing key common technologies, creating new resources, and carrying out customized services according to innovative needs; carrying out scientific popularization for the society; carrying out international exchange and cooperation on strain resources, participating in relevant international academic organizations, and safeguarding national interests and Security
The IPD-IMGT/HLA Database provides a specialist database for sequences of the human major histocompatibility complex (MHC) and includes the official sequences named by the WHO Nomenclature Committee For Factors of the HLA System. The IPD-IMGT/HLA Database is part of the international ImMunoGeneTics project (IMGT). The database uses the 2010 naming convention for HLA alleles in all tools herein. To aid in the adoption of the new nomenclature, all search tools can be used with both the current and pre-2010 allele designations. The pre-2010 nomenclature designations are only used where older reports or outputs have been made available for download.
The Migrant Integration Policy Index (MIPEX) is a unique tool that measures policies to integrate migrants in all EU Member States, Australia, Canada, Iceland, Japan, South Korea, New Zealand, Norway, Switzerland, Turkey and the USA. 167 policy indicators have been developed to create a rich, multi-dimensional picture of migrants’ opportunities to participate in society. The index is a useful tool to evaluate and compare what governments are doing to promote the integration of migrants in all the countries analysed.
>>>!!!<<< The repository is no longer available. >>>!!!<<< The eagle-i National Network and eagle-i resource search at www.eagle-.net was retired on November 4, 2021.!!! Groundbreaking biomedical research requires access to cutting edge scientific resources; however such resources are often invisible beyond the laboratories or universities where they were developed. eagle-i is a discovery platform that helps biomedical scientists find previously invisible, but highly valuable, resources.
The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. It is intended as a “one-stop shop” portal to pharmacological information and its main aim is to provide a searchable database with quantitative information on drug targets and the prescription medicines and experimental drugs that act on them. In future versions we plan to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. We hope that the IUPHAR/BPS Guide to PHARMACOLOGY (abbreviated as GtoPdb) will be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.
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The center's main task is to introduce, collect and preserve dog laboratory animal varieties, strains, develop and maintain new technologies, cultivate new varieties and strains, and provide standard experimental seeds. In 2019, the Ministry of Science and Technology and the Ministry of Finance, for the purpose of improving the scientific and technological resources sharing service system, promoted the opening and sharing of scientific and technological resources to society, and carried out the optimization and adjustment of the national platform. The National Canine Laboratory Animal Seed Center was successfully approved as the only "National Canine Laboratory Animal Resource Center".
The mission of the GO Consortium is to develop a comprehensive, computational model of biological systems, ranging from the molecular to the organism level, across the multiplicity of species in the tree of life. The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes. This knowledge is both human-readable and machine-readable, and is a foundation for computational analysis of large-scale molecular biology and genetics experiments in biomedical research.
IPM Images is a project of the University of Georgia’s Center for Invasive Species and Ecosystem Health and one of the four major parts of BugwoodImages. The Focus is on Integrated Pest Management. It provides an easily accessible archive of high quality images for use in educational applications. In most cases, the images found in this system were taken by and loaned to us by photographers other than ourselves. Most are in the realm of public sector images. The photographs are in this system to be used
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The WURM project is a database of computed Raman and infrared spectra and other physical properties for minerals. The calculations are performed within the framework of the density-functional theory and the density-functional perturbation theory. The database is freely available for teaching and research purposes and is presented in a web-based format, hosted on the https://www.wurm.info/ web site. It provides the crystal structure, the parameters of the calculations, the dielectric properties, the Raman spectra with both peak positions and intensities and the infrared spectra with peak positions for minerals. It shows the atomic displacement patterns for all the zone-center vibrational modes and the associated Raman tensors. The web presentation is user friendly and highly oriented toward the end user, with a strong educational component in mind. A set of visualization tools ensures the observation of the crystal structure, the vibrational pattern, and the different spectra. Further developments include elastic and optical properties of minerals.
Country
The Swedish Human Protein Atlas project has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and cells assembled in tissue microarrays. Confocal microscopy analysis using human cell lines is performed for more detailed protein localization. The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput production method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). After purification, the antibodies are used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of platforms.
The CGSC Database of E. coli genetic information includes genotypes and reference information for the strains in the CGSC collection, the names, synonyms, properties, and map position for genes, gene product information, and information on specific mutations and references to primary literature. The public version of the database includes this information and can be queried directly via this CGSC DB WebServer
The International Ocean Discovery Program’s (IODP) Gulf Coast Repository (GCR) is located in the Research Park on the Texas A&M University campus in College Station, Texas. This repository stores DSDP, ODP, and IODP cores from the Pacific Ocean, the Caribbean Sea and Gulf of Mexico, and the Southern Ocean. A satellite repository at Rutgers University houses New Jersey/Delaware land cores 150X and 174AX.
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DAIS - Digital Archive of the Serbian Academy of Sciences and Arts is a joint digital repository of the Serbian Academy of Sciences and Arts (SASA) and the research institutes under the auspices of SASA. The aim of the repository is to provide open access to publications and other research outputs resulting from the projects implemented by the SASA and its institutes. The repository uses a DSpace-based software platform developed and maintained by the Belgrade University Computer Centre (RCUB).
The Mexican Health and Aging Study (MHAS) started as a prospective panel study of health and aging in Mexico. MHAS is nationally representative of the 13 million Mexicans born prior to 1951. The survey has national and urban/rural representation. The baseline survey, in 2001, included a nationally representative sample of Mexicans aged 50 and over and their spouse/partners regardless of their age. A direct interview was sought with each individual and proxy interviews were obtained when poor health or temporary absence precluded a direct interview. The sample was distributed in all 32 states of the country in urban and rural areas. Households in the six states which account for 40% of all migrants to the U.S. were over-sampled. A sub-sample was selected to obtain anthropometric measures.
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<<<!!!<<< This repository is no longer available. PLEASE NOTE: Unfortunately, the Hustedt collection cannot be used at the moment. Since the collection was previously located in our section, this page can still be found here. We hope to be able to provide information on the further use of the collection shortly. https://www.awi.de/en/science/biosciences/polar-biological-oceanography/main-research-focus/hustedt-diatom-study-centre.html >>>!!!>>>
The International Ocean Discovery Program (IODP) is an international marine research collaboration that explores Earth's history and dynamics using ocean-going research platforms to recover data recorded in seafloor sediments and rocks and to monitor subseafloor environments. IODP depends on facilities funded by three platform providers with financial contributions from five additional partner agencies. Together, these entities represent 26 nations whose scientists are selected to staff IODP research expeditions conducted throughout the world's oceans. IODP expeditions are developed from hypothesis-driven science proposals aligned with the program's science plan Illuminating Earth's Past, Present, and Future. The science plan identifies 14 challenge questions in the four areas of climate change, deep life, planetary dynamics, and geohazards. Until 2013 under the name: International Ocean Drilling Program.
Rhea is a freely available and comprehensive resource of expert-curated biochemical reactions. It has been designed to provide a non-redundant set of chemical transformations for applications such as the functional annotation of enzymes, pathway inference and metabolic network reconstruction. There are three types of reaction participants (reactants and products): Small molecules, Rhea polymers, Generic compounds. All three types of reaction participants are linked to the ChEBI database (Chemical Entities of Biological Interest) which provides detailed information about structure, formula and charge. Rhea provides built-in validations that ensure both mass and charge balance of the reactions. We have populated the database with the reactions found in the enzyme classification (i.e. in the IntEnz and ENZYME databases), extending it with additional known reactions of biological interest. While the main focus of Rhea is enzyme-catalysed reactions, other biochemical reactions (including those that are often termed "spontaneous") also are included.
The EZRC at KIT houses the largest experimental fish facility in Europe with a capacity of more than 300,000 fish. Zebrafish stocks are maintained mostly as frozen sperm. Frequently requested lines are also kept alive as well as a selection of wildtype strains. Several thousand mutations in protein coding genes generated by TILLING in the Stemple lab of the Sanger Centre, Hinxton, UK and lines generated by ENU mutagenesis by the Nüsslein-Volhard lab in addition to transgenic lines and mutants generated by KIT groups or brought in through collaborations. We also accept submissions on an individual basis and ship fish upon request to PIs in Europe and elsewhere. EZRC also provides screening services and technologies such as imaging and high-throughput sequencing. Key areas include automation of embryo handling and automated image acquisition and processing. Our platform also involves the development of novel microscopy techniques (e.g. SPIM, DSLM, robotic macroscope) to permit high-resolution, real-time imaging in 4D. By association with the ComPlat platform, we can support also chemical screens and offer libraries with up to 20,000 compounds in total for external users. As another service to the community the EZRC provides plasmids (cDNAs, transgenes, Talen, Crispr/cas9) maintained by the Helmholtz repository of Bioparts (HERBI) to the scientific community. In addition the fish facility keeps a range of medaka stocks, maintained by the Loosli group.
We are a leading international centre for genomics and bioinformatics research. Our mandate is to advance knowledge about cancer and other diseases, to improve human health through disease prevention, diagnosis and therapeutic approaches, and to realize the social and economic benefits of genomics research.
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National Aquatic Biological Resource Center (NABRC), established in June 2019, is a member of National Science and Technology Resource Platform supported by the Ministry of Science and Technology and the Ministry of Finance. The NABRC consists of 6 sub-platforms. In summary, these six sub-platforms have reached leading levels at home and abroad in terms of the resource richness, the resource digitization, as well as the amount and quality of resource services. Right now, these platforms are in strong support of basic biology, basic medicine, aquatic economics, water environmental protection and other areas in China. It is an essential way to practice the "Great Yangtze River Protection" and promote the construction of ecological civilization in the Yangtze River. In the future, the platforms will further integrate different types of resources, optimize the resource configuration and improve the service systems, so as to build a high standard resource sharing platform on a global scale and promote international communication and cooperation.