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The Department of Energy Systems Biology Knowledgebase (KBase) is a software and data platform designed to meet the grand challenge of systems biology: predicting and designing biological function. KBase integrates data and tools in a unified graphical interface so users do not need to access them from numerous sources or learn multiple systems in order to create and run sophisticated systems biology workflows. Users can perform large-scale analyses and combine multiple lines of evidence to model plant and microbial physiology and community dynamics. KBase is the first large-scale bioinformatics system that enables users to upload their own data, analyze it (along with collaborator and public data), build increasingly realistic models, and share and publish their workflows and conclusions. KBase aims to provide a knowledgebase: an integrated environment where knowledge and insights are created and multiplied.
ScienceBase provides access to aggregated information derived from many data and information domains, including feeds from existing data systems, metadata catalogs, and scientists contributing new and original content. ScienceBase architecture is designed to help science teams and data practitioners centralize their data and information resources to create a foundation needed for their work. ScienceBase, both original software and engineered components, is released as an open source project to promote involvement from the larger scientific programming community both inside and outside the USGS.