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Found 9 result(s)
The IMPC is a confederation of international mouse phenotyping projects working towards the agreed goals of the consortium: To undertake the phenotyping of 20,000 mouse mutants over a ten year period, providing the first functional annotation of a mammalian genome. Maintain and expand a world-wide consortium of institutions with capacity and expertise to produce germ line transmission of targeted knockout mutations in embryonic stem cells for 20,000 known and predicted mouse genes. Test each mutant mouse line through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease. Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems; Maintain and expand collaborative “networks” with specialist phenotyping consortia or laboratories, providing standardized secondary level phenotyping that enriches the primary dataset, and end-user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research; and Provide a centralized data centre and portal for free, unrestricted access to primary and secondary data by the scientific community, promoting sharing of data, genotype-phenotype annotation, standard operating protocols, and the development of open source data analysis tools. Members of the IMPC may include research centers, funding organizations and corporations.
The US Virtual Astronomical Observatory (VAO) is the VO effort based in the US, and it is one of many VO projects currently underway worldwide. The primary emphasis of the VAO is to provide new scientific research capabilities to the astronomy community. Thus an essential component of the VAO activity is obtaining input from US astronomers about the research tools that are most urgently needed in their work, and this information will guide the development efforts of the VAO. >>>!!!<<< Funding discontinued in 2014 and all software, documentation, and other digital assets developed under the VAO are stored in the VAO Project Repository https://sites.google.com/site/usvirtualobservatory/ . Code is archived on Github https://github.com/TomMcGlynn/usvirtualobservatory . >>>!!!<<<
The European Nucleotide Archive (ENA) captures and presents information relating to experimental workflows that are based around nucleotide sequencing. A typical workflow includes the isolation and preparation of material for sequencing, a run of a sequencing machine in which sequencing data are produced and a subsequent bioinformatic analysis pipeline. ENA records this information in a data model that covers input information (sample, experimental setup, machine configuration), output machine data (sequence traces, reads and quality scores) and interpreted information (assembly, mapping, functional annotation). Data arrive at ENA from a variety of sources. These include submissions of raw data, assembled sequences and annotation from small-scale sequencing efforts, data provision from the major European sequencing centres and routine and comprehensive exchange with our partners in the International Nucleotide Sequence Database Collaboration (INSDC). Provision of nucleotide sequence data to ENA or its INSDC partners has become a central and mandatory step in the dissemination of research findings to the scientific community. ENA works with publishers of scientific literature and funding bodies to ensure compliance with these principles and to provide optimal submission systems and data access tools that work seamlessly with the published literature.
InnateDB is a publicly available database of the genes, proteins, experimentally-verified interactions and signaling pathways involved in the innate immune response of humans, mice and bovines to microbial infection. The database captures an improved coverage of the innate immunity interactome by integrating known interactions and pathways from major public databases together with manually-curated data into a centralised resource. The database can be mined as a knowledgebase or used with our integrated bioinformatics and visualization tools for the systems level analysis of the innate immune response.
Arca Data is Fiocruz's official repository for archiving, publishing, disseminating, preserving and sharing digital research data produced by the Fiocruz community or in partnership with other research institutes or bodies, with the aim of promoting new research, ensuring the reproducibility or replicability of existing research and promoting an Open and Citizen Science. Its objective is to stimulate the wide circulation of scientific knowledge, strengthening the institutional commitment to Open Science and free access to health information, in addition to providing transparency and fostering collaboration between researchers, educators, academics, managers and graduate students, to the advancement of knowledge and the creation of solutions that meet the demands of society.
The NDEx Project provides an open-source framework where scientists and organizations can share, store, manipulate, and publish biological network knowledge. The NDEx Project maintains a free, public website; alternatively, users can also decide to run their own copies of the NDEx Server software in cases where the stored networks must be kept in a highly secure environment (such as for HIPAA compliance) or where high application load is incompatible with a shared public resource.
The World Stress Map (WSM) is a global compilation of information on the crustal present-day stress field maintained since 2009 at the Helmholtz Centre Potsdam GFZ German Research Centre for Geosciences. It is a collaborative project between academia and industry that aims to characterize the crustal stress pattern and to understand the stress sources. All stress information is analysed and compiled in a standardized format and quality-ranked for reliability and comparability on a global scale. The WSM is an open-access public database and is used by various academic and industrial institutions working in a wide range of Earth science disciplines such as geodynamics, hazard assessment, hydrocarbon exploitations and engineering.